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Combined immunization with HPV-g Bsec and HPV-g Dsec (HPV-g Bsec/g Dsec) vaccines conferred longer survival after vaginal challenge with HSV-2 than immunization with HPV-g Bsec or HPV-g Dsec alone.
HPV-g Bsec/g Dsec ivag vaccination was associated with a reduced severity of genital lesions and lower levels of viral shedding in the genital tract after HSV-2 challenge.
Vaccination combining ivag HPV-g Bsec/g Dsec and i.m.
HPV is so common that nearly all sexually active men and women get it at some point in their lives.
HPV is associated with a number of cancers including cervical cancer and cancer of the vulva, vagina, penis, and rectal cancer.
g D2t-alum-MPL improved survival and reduced genital lesions and viral shedding.
Finally, high levels of circulating HSV-2-specific CD8 T cells, but not serum antibodies, correlated with reduced viral shedding.
No herpes simplex virus 2 (HSV-2) vaccine has been licensed for use in humans.